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BLOOD PROCESSING
Sepax® (Cell Processing System) Sterile Connecting Device CliniMACS® (Cell Enrichment / Depletion) Plasma Thawing System UltraCW (Automated cell washer)
BLOOD SEPARATION BLOOD SCREENING BLOOD STORAGE BLOOD COLLECTION
SEPAX - CELL PROCESSING SYSTEM
SEPAX SYSTEM COOLMIX AS-210 RED CELL FREEZING AND THAWING

SEPAX SYSTEM  

The Sepax cell separation system is a modern cell centrifugation device for fast and automated processing of blood and its components.
    Product features:
    TraceabilityAS-610:
  • An important tool which gives the possibility to keep both technical and patient data for each procedure performed with the Sepax system. Data for all procedures can be saved in the Sepax memory card and also be printed.

    The traceability features and devices include a thermal printer, a bar code reader, managing software, cables and connector protections.
    Applications:
    Umbilical Cord Blood Processing:

    Biosafe provides three protocols to process umbilical cord blood:
    • Umbilical Cord Blood-HES (UCB-HES): It is based on the sedimentation agent Hydro-Ethyl Starch.
    • Umbilical Cord Blood processing (UCB)- No Additives: This protocol does not require additives. This separation protocol is ideally suited to UCB banking where storage costs need to be minimized and the use of additives is a concern.
    • Umbilical Cord Blood-Low Buffy-Coat Volume (UCB-LBC): This protocol produces very small buffy-coat volume.
    • Umbilical Cord Blood Stem Cell Washing Protocol-Post Thawing (The UCB Washing Protocol): This protocol is designed for automated washing of thawed cord blood units in a closed system. The washed Cells are viable for hours which also allow further processing without time constraints. This washing protocol is recommended when a safe and automated removal of DMSO and hemolysed plasma from thawed UCB products is desired.
    • Peripheral Blood Processing:
      Biosafe provides two protocols to process PBSC products:
    • PBSC Volume Reduction: This protocol is designed for reducing volume of peripheral blood stem cell (PBSC) preparations after leukapheresis. The hematopoietic stem cells can then be frozen and stored until future transplantation into a patient. This protocol is recom- mended when optimization of cell concentration and reduction of DMSO toxicity are a concern.
    • Peripheral Blood Stem Cell Washing: This protocol is designed for automated and safe removal of DMSO and hemolysed plasma from thawed leucapheresis products. The washed cells are viable for hours which also enable further process without time constraints.
    Bone Marrow Processing:
      Biosafe provides two protocols:
    • The Generic Volume Reduction Protocol: This protocol is designed for efficient separation of stem cells in a closed system. This protocol is conceived for volume reduction of different blood products and specially adapted for bone marrow applications in transplantation and regenerative medicine applications.
    • The Density Gradient based Separation Protocol: This protocol is designed for bone marrow or umbilical cord blood processing in regenerative medicine applications. This protocol is recommended when optimization of cell concentration and high depletion of RBC are a concern.

COOLMIX AS-210 

It is an automated mixing and cooling device that allows controlled and reproducible preparation of haematopoietic stem cells for cryopreservation in a closed and sterile environment. Designed to be used with either gravity-fed or injection-pumped DMSO cryopreservant, the Coolmix can accommodate cryobags from both the Sepax CS-530 and CS-540 single-use kits.
    Product features:
  • Cools and stabiIizes cryobag temperature
  • Mixes DMSO homogeneously
  • Allows reproducible cooling and mixing of haematopoietic stem eel Is Metal storage canister
  • Aluminium alloy canister
  • Enhanced thermal conductivity material for homogeneous product freezing Canister opening tool
  • Stainless steel tool
  • Easy and fast canister opening Overwrap bag air
    • EVO material remains flexible in liquid nitrogen (-196°C)
    • Easy insertion and inspection of the contents
    • Recommended for use with Biosafe overwrap seal ing device
    Overwrap bag sealer + air-purger
    • Sealer for Biosafe overwrap bag
    • Equipped with air purger
    • Selectable parameters:
      -Sealing temperature
      -Sealing time
      -Cooling time
    Syringe pump device
    • Controls injection of DMSO solution in the cryobag
    • Can hold one or two syringes
    • Supplied with security system
    • Selectable parameters: -Syringe size -Injected volume -Injection flow rate

3. RED CELL FREEZING AND THAWING 

HAEMONETICS ACP215 AUTOMATED CELL PROCESSING SYSTEM The ACP 215 system extends the shelf life of thawed blood from 24 hours to 14 days. This extended shelf life greatly extends the value of frozen blood and has the potential to expand its use from rare blood reserves to emergency strategic reserves. Product Features:

Automated Closed System
  • Closed system
  • Automated glycerolization and deglycerolization
  • Small footprint Integrated Process Control
  • Better GMP compliance
  • Makes quality control easy and cost effective
  • Provides traceability reports
Extended Post-Thaw Storage
  • Stores red cells in additive solution after thawing
  • Makes frozen blood a desirable choice, especially for rare units
  • Improves logistics Inventory Management
  • Rare blood type inventory
  • Emergency source during seasonal shortages
  • Autologous blood management
 
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